Weight loss-induced increase in fasting ghrelin concentration is a predictor of weight regain: Evidence from the Diabetes Remission Clinical Trial (DiRECT).
George ThomAlasdair McIntoshClaudia-Martina MessowWilma S LeslieAlison C BarnesNaomi T BrosnahanLouise McCombieDalia MalkovaAhmad Al-MrabehSviatlana ZhyzhneuskayaPaul WelshNaveed SattarRoy TaylorMichael E J LeanPublished in: Diabetes, obesity & metabolism (2020)
The rise in ghrelin (but not any other measured hormone) during diet-induced weight loss was a predictor of weight regain during follow-up, and concentrations remained elevated over time, suggesting a small but significant compensatory drive to regain weight. Attenuating the effects of ghrelin may improve weight-loss maintenance.
Keyphrases
- high glucose
- weight loss
- gastric bypass
- bariatric surgery
- roux en y gastric bypass
- glycemic control
- clinical trial
- weight gain
- blood glucose
- type diabetes
- obese patients
- cardiovascular disease
- growth hormone
- insulin resistance
- disease activity
- physical activity
- randomized controlled trial
- body mass index
- open label
- oxidative stress
- study protocol
- phase ii
- drug induced
- diabetic rats