The Importance of Animal Models in Biomedical Research: Current Insights and Applications.
Adriana Domínguez-OlivaIsmael Hernández-ÁvalosJulio Martínez-BurnesAdriana Olmos-HernándezAntonio Verduzco-MendozaDaniel Mota-RojasPublished in: Animals : an open access journal from MDPI (2023)
Animal research is considered a key element in advance of biomedical science. Although its use is controversial and raises ethical challenges, the contribution of animal models in medicine is essential for understanding the physiopathology and novel treatment alternatives for several animal and human diseases. Current pandemics' pathology, such as the 2019 Coronavirus disease, has been studied in primate, rodent, and porcine models to recognize infection routes and develop therapeutic protocols. Worldwide issues such as diabetes, obesity, neurological disorders, pain, rehabilitation medicine, and surgical techniques require studying the process in different animal species before testing them on humans. Due to their relevance, this article aims to discuss the importance of animal models in diverse lines of biomedical research by analyzing the contributions of the various species utilized in science over the past five years about key topics concerning human and animal health.
Keyphrases
- public health
- endothelial cells
- coronavirus disease
- type diabetes
- healthcare
- induced pluripotent stem cells
- chronic pain
- metabolic syndrome
- pluripotent stem cells
- cardiovascular disease
- weight loss
- neuropathic pain
- combination therapy
- health information
- physical activity
- body mass index
- spinal cord
- risk assessment
- high fat diet induced
- weight gain
- skeletal muscle
- cerebral ischemia
- mental health
- smoking cessation
- decision making
- adipose tissue
- replacement therapy