Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.

Shaoxing Guan Xi Chen Yuru Wei Fei Wang Wen Xie Youhao Chen Heng Liang Xia Zhu Yunpeng Yang Wenfeng Fang Yan Huang Hongyun Zhao Xiao-Xu Zhang Shu Liu Wei Zhuang Min Huang Xue-Ding Wang Li Zhang

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

These findings characterized rs3744797 as an oncogenic variant in mediating EGFR-TKI resistance and tumor aggressiveness through deubiquitinating MLLT3, highlighting the variant as a predictive biomarker for EGFR-TKI response in NSCLC.

Keyphrases

tyrosine kinase
small cell lung cancer
epidermal growth factor receptor
advanced non small cell lung cancer
poor prognosis
dna repair
binding protein