Fibroblast growth factor 2 regulates cumulus differentiation under the control of the oocyte.

Rodrigo G BarrosPaula F LimaAna Caroline S SoaresLorena SanchesChristopher A PriceJosé Buratini

Published in: Journal of assisted reproduction and genetics (2019)

This is the first study showing that FGF2 expression is regulated by the oocyte in cumulus cells. Moreover, we report novel effects of FGF2 on cumulus cell survival and extracellular matrix (ECM) quality during IVM that may favor acquisition of developmental competence and suggest physiological roles during the final steps of COC differentiation.

Keyphrases

extracellular matrix
induced apoptosis
poor prognosis
cell cycle arrest
cell death
quality improvement
signaling pathway
oxidative stress
long non coding rna
cell proliferation