Recent advances in nanomaterials for neural applications: opportunities and challenges.
Natarajan SisubalanRamadoss ShaliniSakthivel RamyaBhagavathi Sundaram SivamaruthiChaiyavat ChaiyasutPublished in: Nanomedicine (London, England) (2023)
Nanomedicines are promising for delivering drugs to the central nervous system, though their precision is still being improved. Fortifying nanoparticles with vital molecules can interact with the blood-brain barrier, enabling access to brain tissue. This study summarizes recent advances in nanomedicine to treat neurological complications. The integration of nanotechnology into cell biology aids in the study of brain cells' interactions. Magnetic microhydrogels have exhibited superior neuron activation compared with superparamagnetic iron oxide nanoparticles and hold promise for neuropsychiatric disorders. Nanomaterials have shown notable results, such as tackling neurodegenerative diseases by hindering harmful protein buildup and regulating cellular processes. However, further studies of the safety and effectiveness of nanoparticles in managing neurological diseases and disorders are still required.
Keyphrases
- iron oxide nanoparticles
- randomized controlled trial
- induced apoptosis
- resting state
- systematic review
- cerebral ischemia
- stem cells
- risk factors
- cell therapy
- multiple sclerosis
- mesenchymal stem cells
- cell death
- signaling pathway
- cell cycle arrest
- functional connectivity
- binding protein
- small molecule
- amino acid
- mass spectrometry
- deep learning
- endoplasmic reticulum stress
- subarachnoid hemorrhage
- cancer therapy
- protein protein
- pi k akt
- drug induced
- liquid chromatography