Regorafenib inhibited gastric cancer cells growth and invasion via CXCR4 activated Wnt pathway.

Xiao-Lin LinQi XuLei TangLi SunTing HanLi-Wei WangXiu-Ying Xiao

Published in: PloS one (2017)

Our findings demonstrated that regorafenib effectively inhibited cell proliferation and invasion of gastric cancer cells via decreasing the expression of CXCR4 and further reducing the transcriptional activity of Wnt/β-Catenin pathway.

Keyphrases

cell migration
metastatic colorectal cancer
cell proliferation
stem cells
poor prognosis
single cell
cell therapy
gene expression
transcription factor
binding protein
heat shock