Doxorubicin modulated clock genes and cytokines in macrophages extracted from tumor-bearing mice.
Alexandre Abilio S TeixeiraLuana Amorim BiondoLoreana Sanches SilveiraEdson Alves de Lima JuniorHelena Angelica Pereira BatatinhaTiego Aparecido DinizCamila Oliveira de SouzaJeferson CominJose Cesar Rosa NetoPublished in: Cancer biology & therapy (2020)
DOX treatment in vivo disrupted cytokine and clock genes expression in intraperitoneal macrophages suppressing immune response. Moreover, macrophages cultured with DOX had decreased expression of LPS-stimulated inflammatory cytokines.