Circulating Free Fatty Acid and Phospholipid Signature Predicts Early Rapid Kidney Function Decline in Patients With Type 1 Diabetes.
Farsad AfshinniaThekkelnaycke M RajendiranChenchen HeJaeman ByunDaniel MontemayorManjula DarshiJana TumovaJiwan KimChristine P LimonteRachel G MillerTina CostacouTrevor J OrchardTarunveer S AhluwaliaEllen BurgessJanet K Snell-BergeonIan H de BoerLoki NatarajanGeorge MichailidisKumar SharmaSubramaniam PennathurPublished in: Diabetes care (2021)
Distinct from previously reported predictors of GFR decline in type 2 diabetes, these findings suggest differential incorporation of FFAs at the sn1 carbon of the phospholipids' glycerol backbone as an independent predictor of rapid GFR decline in T1D.