Immune correlates of Mycobacterium Tuberculosis patients in Zambia stratified by HIV serostatus and level of immunity-a cross-sectional analytical laboratory based study.
Patrick Saili LunguEvarist NjelesaniThomas SukwaOwen NgalamikaSody MunsakaWilliam KilembeShabir LakhiPeter MwabaPublished in: PloS one (2022)
This study suggests that HIV seronegative TB patients have a higher pro-inflammatory response to MTB than HIV seropositive TB patients. Further, it also shows that the level of CD4 influences immunomodulation. The findings suggest that the difference in cytokine expression may be responsible for the distinct patterns of TB presentation between HIV positive and HIV negative patient.
Keyphrases
- hiv positive
- mycobacterium tuberculosis
- antiretroviral therapy
- end stage renal disease
- men who have sex with men
- human immunodeficiency virus
- hiv infected
- ejection fraction
- hiv testing
- chronic kidney disease
- south africa
- hepatitis c virus
- hiv aids
- poor prognosis
- case report
- patient reported outcomes
- pulmonary tuberculosis
- binding protein