Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade.

Liam Jenkins Ute Jungwirth Alexandra Avgustinova Marjan Iravani Adam MillsSyed HaiderJames HarperClare M Isacke

Published in: Cancer research (2022)

Paired syngeneic models help unravel the interplay between CAF and tumor immune evasion, highlighting the benefits of targeting fibroblast subpopulations to improve clinical responses to immunotherapy.

Keyphrases

cancer therapy
extracellular matrix