RNA Helicase DDX5 Maintains Cardiac Function by Regulating CamkIIδ Alternative Splicing.
Kangni JiaHaomai ChengWen-Qi MaLingfang ZhuangHao LiZhigang LiZiyang WangHang SunYuke CuiHang ZhangHongyang XieLei YiZhiyong ChenMotoaki SanoKeiichi FukudaLin LuJun PuYan ZhangLing GaoRuiyan ZhangXiaoxiang YanPublished in: Circulation (2024)
These findings reveal a role for DDX5 in maintaining calcium homeostasis and cardiac function by regulating alternative splicing in cardiomyocytes, identifying the DDX5 as a potential target for therapeutic intervention in HF.