Curcumin Combined with Thalidomide Reduces Expression of STAT3 and Bcl-xL, Leading to Apoptosis in Acute Myeloid Leukemia Cell Lines.

Mahnaz Mohammadi KianMahdieh SalemiMohammad BahadoranAtousa HaghiNasrin DashtiSaeed MohammadiShahrbano RostamiBahram ChahardouliDavood BabakhaniMohsen Nikbakht

Published in: Drug design, development and therapy (2020)

Overall, our findings suggested that down-regulation of STAT3 and BCL-XL mRNA expression in response to CUR and THAL treatment lead to inhibition of cell growth and induction of apoptosis.

Keyphrases

endoplasmic reticulum stress
cell cycle arrest
oxidative stress
cell death
cell proliferation
poor prognosis
binding protein
long non coding rna