Asparaginase-associated Pancreatitis Complicated by Pancreatic Fluid Collection Treated with Endoscopic Cistogastrostomy in Pediatric Acute Lymphoblastic Leukemia: A Case Report and Systematic Review of the Literature.
Giulia FiumanaAlessia PancaldiHelga BertaniValentina BoarinoMonica CelliniLorenzo IughettiPublished in: Clinical hematology international (2023)
Asparaginase-associated pancreatitis complicates 2-10% of patients treated for acute lymphoblastic leukemia, causing morbidity and discontinuation of asparaginase administration. Among acute complications, pancreatic fluid collections can be managed conservatively, but intervention is indicated when associated with persistent insulin therapy need and recurrent abdominal pain. Endoscopic treatment has become the standard approach in adult patients, with increasing favorable evidence in children. This work compares the characteristics of a pediatric oncology patient treated at our institution with reported literature experiences, showing feasibility, safety and effectiveness of endoscopic approach.
Keyphrases
- acute lymphoblastic leukemia
- ultrasound guided
- abdominal pain
- randomized controlled trial
- systematic review
- allogeneic hematopoietic stem cell transplantation
- type diabetes
- liver failure
- young adults
- mental health
- palliative care
- case report
- respiratory failure
- drug induced
- newly diagnosed
- stem cells
- intensive care unit
- bone marrow
- insulin resistance
- combination therapy
- replacement therapy
- hepatitis b virus
- extracorporeal membrane oxygenation