Performance of the Framingham risk models and pooled cohort equations for predicting 10-year risk of cardiovascular disease: a systematic review and meta-analysis.
Johanna A A G DamenRomin PajouheshniaPauline HeusKarel G M MoonsJohannes B ReitsmaRob J P M ScholtenLotty HooftThomas P A DebrayPublished in: BMC medicine (2019)
The Framingham Wilson, ATP III and PCE discriminate comparably well but all overestimate the risk of developing CVD, especially in higher risk populations. Because the extent of miscalibration substantially varied across settings, we highly recommend that researchers further explore reasons for overprediction and that the models be updated for specific populations.