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MicroRNA-200b is a potential biomarker of the expression of PD-L1 in patients with lung cancer.

Seigo KatakuraNobuaki KobayashHisashi HashimotoChisato KamimakiKatsushi TanakaSousuke KuboKentaro NakashimaShuhei TeranishiSaki ManabeKeisuke WatanabeNobuyuki HoritaYu HaraMasaki YamamotoMakoto KudoHongmei PiaoTakeshi Kaneko
Published in: Thoracic cancer (2020)
SIGNIFICANT FINDINGS OF THE STUDY: High PD-L1 expression was linked to low miR200b expression, whereas low PD-L1 expression was linked to high miR200b expression in human lung cancer patients. Thus, miR200b overexpression or silencing can control PD-L1 expression in cancer cells. What this study adds We demonstrated the potential of miR200b as a surrogate biomarker for PD-L1 expression in lung cancer patients.
Keyphrases
  • poor prognosis
  • binding protein
  • cell proliferation
  • transcription factor
  • risk assessment