Copy number of 8q24.3 drives HSF1 expression and patient outcome in cancer: an individual patient data meta-analysis.
Nele BrusselaersKarl EkwallMickael Durand-DubiefPublished in: Human genomics (2019)
Here, we show that CNAs of 8q24.3 genes, including HSF1, are tightly linked to 8q24.3 copy number in tumor patients and can affect patient outcome. Our results indicate that the integration of 8q24.3 CNA detection may be a useful predictor for cancer prognosis.
Keyphrases
- copy number
- mitochondrial dna
- genome wide
- case report
- systematic review
- papillary thyroid
- end stage renal disease
- dna methylation
- squamous cell
- chronic kidney disease
- poor prognosis
- newly diagnosed
- ejection fraction
- squamous cell carcinoma
- peritoneal dialysis
- electronic health record
- prognostic factors
- gene expression
- meta analyses
- oxidative stress
- long non coding rna
- transcription factor
- artificial intelligence
- loop mediated isothermal amplification