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Emerging roles of plasmacytoid dendritic cell crosstalk in tumor immunity.

Leilei YangSongya LiLiuhui ChenYi Zhang
Published in: Cancer biology & medicine (2023)
Plasmacytoid dendritic cells (pDCs) are a pioneer cell type that produces type I interferon (IFN-I) and promotes antiviral immune responses. However, they are tolerogenic and, when recruited to the tumor microenvironment (TME), play complex roles that have long been a research focus. The interactions between pDCs and other components of the TME, whether direct or indirect, can either promote or hinder tumor development; consequently, pDCs are an intriguing target for therapeutic intervention. This review provides a comprehensive overview of pDC crosstalk in the TME, including crosstalk with various cell types, biochemical factors, and microorganisms. An in-depth understanding of pDC crosstalk in TME should facilitate the development of novel pDC-based therapeutic methods.
Keyphrases
  • dendritic cells
  • immune response
  • regulatory t cells
  • randomized controlled trial
  • stem cells
  • optical coherence tomography
  • cell therapy
  • mesenchymal stem cells
  • bone marrow
  • inflammatory response