A network meta-analysis of randomized controlled trials comparing the effectiveness and safety of voclosporin or tacrolimus plus mycophenolate mofetil as induction treatment for lupus nephritis.

Published in: Zeitschrift fur Rheumatologie (2021)

Tacrolimus + MMF and voclosporin + MMF were more effective than monotherapy, and tacrolimus + MMF was the most effective induction treatment for lupus nephritis patients. However, tacrolimus + MMF did pose a greater risk of serious adverse events than monotherapy.

Keyphrases

combination therapy
end stage renal disease
chronic kidney disease
newly diagnosed
ejection fraction
randomized controlled trial
open label
clinical trial