Patterns of benzodiazepine underdosing in the Established Status Epilepticus Treatment Trial.
Abhishek G SatheEllen UnderwoodLisa D ColesJordan J ElmRobert S SilbergleitJames M ChamberlainJaideep KapurHannah R CockNathan B FountainShlomo ShinnarDaniel H LowensteinEric S RosenthalRobin A ConwitThomas P BleckJames C CloydPublished in: Epilepsia (2021)
Benzodiazepines as first-line treatment of SE, particularly midazolam and lorazepam, are frequently underdosed throughout the United States. This broad and generalizable cohort confirms prior single site reports that underdosing is both pervasive and difficult to remediate. (ESETT ClinicalTrials.gov identifier: NCT01960075.).