Program of Rehabilitative Exercise and Education to Avert Vascular Events After Non-Disabling Stroke or Transient Ischemic Attack (PREVENT Trial): A Randomized Controlled Trial.
MacKay-Lyons MarilynGubitz GordonPhillips StephenGiacomantonio NicholasFirth WandaThompson KaraTheriault ChrisWightman HowardSlipp SharonMarsters DavidGail A EskesPeacock FionaBlanchard ChrisDewolfe JudyPublished in: Neurorehabilitation and neural repair (2021)
Impact of PREVENT on vascular risk factor reduction was more modest than anticipated, possibly because several outcome variables approximated normative values at baseline and training intensity may have been sub-optimal. Further investigation is warranted to determine when exercise and education programs are viable adjuncts to pharmaceutical management for reduction of risk factors for second stroke.Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: #NCT00885456.
Keyphrases
- high intensity
- clinical trial
- quality improvement
- cerebral ischemia
- atrial fibrillation
- healthcare
- phase ii
- study protocol
- phase iii
- physical activity
- risk factors
- resistance training
- public health
- randomized controlled trial
- subarachnoid hemorrhage
- open label
- brain injury
- blood brain barrier
- ischemia reperfusion injury
- virtual reality
- body composition
- oxidative stress