Prevalence and Prognostic Role of IDH Mutations in Acute Myeloid Leukemia: Results of the GIMEMA AML1516 Protocol.
Monica MessinaAlfonso PiciocchiTiziana OttoneStefania PaoliniCristina PapayannidisFederica LessiNicola Stefano FracchiollaFabio ForghieriAnna CandoniAndrea MengarelliMaria Paola MartelliAdriano VendittiAngelo Michele CarellaFrancesco AlbanoValentina ManciniBernardi MassimoValentina ArenaValeria SargentiniAlessandra IurloDomenico PastoreElisabetta TodiscoGiovanni RotiSergio SiragusaMarco LadettoStefano PravatoEleonora De BellisFrancesco LanzaGiovanni MarconiClaudio CerchionePaola FaziMarco VignettiSergio AmadoriGiovanni MartinelliMaria Teresa Teresa VosoPublished in: Cancers (2022)
IDH1 / 2 mutations are common in acute myeloid leukemia (AML) and represent a therapeutic target. The GIMEMA AML1516 observational protocol was designed to study the prevalence of IDH1 / 2 mutations and associations with clinico-biological parameters in a cohort of Italian AML patients. We analyzed a cohort of 284 AML consecutive patients at diagnosis, 139 females and 145 males, of a median age of 65 years (range: 19-86). Of these, 38 (14%) harbored IDH1 and 51 (18%) IDH2 mutations. IDH1/2 mutations were significantly associated with WHO PS >2 ( p < 0.001) and non-complex karyotype ( p = 0.021) when compared to IDH1/2 -WT. Furthermore, patients with IDH1 mutations were more frequently NPM1 -mutated ( p = 0.007) and had a higher platelet count ( p = 0.036). At relapse, IDH1 /2 mutations were detected in 6 (25%) patients. As per the outcome, 60.5% of IDH1/2 -mutated patients achieved complete remission; overall survival and event-free survival at 2 years were 44.5% and 36.1%, respectively: these rates were similar to IDH1 / 2 -WT. In IDH1 / 2 -mutated patients, high WBC proved to be an independent prognostic factor for survival. In conclusion, the GIMEMA AML1516 confirms that IDH1 / 2 mutations are frequently detected at diagnosis and underlines the importance of recognizing IDH1 / 2 -mutated cases up-front to offer the most appropriate therapeutic strategy, given the availability of IDH1/2 inhibitors.