The expression of FOXP3 in lesions of several forms of leprosy in patients co-infected with HIV.
Marilia Brasil XavierCarla Andréa Avelar PiresCláudia Maria de Castro GomesGabriela Fernandes RodriguesDébora Pinheiro XavierJoão Augusto Gomes de Souza Monteiro de BritoCarlos Eduardo Pereira CorbettPublished in: PLoS neglected tropical diseases (2021)
These findings support that higher activity of the HIV may stimulate or result in a higher expression of FOXP3-Tregs and that they may be involved in active immunosuppression observed at the infection site at the tissue level. This supports the need to expand studies on FOXP3+ Treg cells in co-infected patients.
Keyphrases
- regulatory t cells
- poor prognosis
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- hepatitis c virus
- end stage renal disease
- newly diagnosed
- induced apoptosis
- hiv aids
- men who have sex with men
- cell cycle arrest
- binding protein
- cell death
- south africa
- immune response
- signaling pathway