The spatiotemporal matching pattern of Ezrin/Periaxin involved in myoblast differentiation and fusion and Charcot-Marie-Tooth disease-associated muscle atrophy.
Ruo-Nan ZhangXin BaoYun LiuYan WangXing-Yuan LiGe TanMagdaleena Naemi MbadhiWei XuQian YangLu-Yuan YaoLong ChenXiao-Ying ZhaoChang-Qing HuJing-Xuan ZhangHong-Tao ZhengYan WuShan LiShao-Juan ChenShi-You ChenJing LvLiu-Liu ShiJun-Ming TangPublished in: Journal of translational medicine (2023)
The spatiotemporal pattern of Ezrin/Periaxin expression was involved in the control of myoblast differentiation/fusion, myotube length and size, and myofiber specialization, which was related to the activated PKA-NFAT-MEF2C signaling pathway, providing a novel L-Periaxin/Ezrin joint strategy for the treatment of muscle atrophy induced by nerve injury, especially in CMT4F.