The crossover design for migraine preventives: an analyses of four randomized placebo-controlled trials.

Astrid Bjørke JenssenLars Jacob StovnerErling TronvikTrond SandGrethe HeldeGøril Bruvik GravdahlKnut Hagen

Published in: The journal of headache and pain (2019)

Summary data from four crossover trials evaluating preventive treatment in adult migraine showed that few dropped out after the first period. No period or carryover effect was found. RCT studies with crossover design can be recommended as an efficient and cost-saving way to evaluate potential new preventive medicines for migraine in adults.

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