Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner.
Josca Mariëtte SchoonejansHeather L BlackmoreThomas J AshmoreCatherine E AikenDenise S Fernandez-TwinnSusan E OzannePublished in: International journal of molecular sciences (2021)
Maternal metformin intervention during obese pregnancy causes excessive adiposity, adipocyte hyperplasia and WAT inflammation in male offspring, highlighting sex-specific effects of prenatal metformin exposure on offspring WAT.
Keyphrases
- high fat diet
- insulin resistance
- adipose tissue
- pregnancy outcomes
- weight gain
- birth weight
- metabolic syndrome
- randomized controlled trial
- pregnant women
- young adults
- weight loss
- type diabetes
- preterm birth
- obese patients
- oxidative stress
- skeletal muscle
- body mass index
- bariatric surgery
- blood glucose
- gestational age
- physical activity