Distribution and favorable prognostic implication of genomic EGFR alterations in IDH-wildtype glioblastoma.

Nayuta HigaToshiaki AkahaneTaiji HamadaHajime YonezawaHiroyuki UchidaRyutaro MakinoShoji WatanabeTomoko TakajoSeiya YokoyamaMari KirishimaKei MatsuoShingo FujioRyosuke HanayaAkihide TanimotoKoji Yoshimoto

Published in: Cancer medicine (2022)

We found that the EGFR gene profiles of GBM differ among cohorts and that EGFR alterations are good prognostic markers of overall survival in patients with IDH-wildtype GBM. Additionally, we identified rare EGFR variants with longitudinal and temporal transformations of EGFRvIII.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
copy number
low grade
genome wide
cross sectional
gene expression
wild type
high grade
genome wide identification