AXL kinase-mediated astrocytic phagocytosis modulates outcomes of traumatic brain injury.
Hang ZhouLibin HuJianru LiWu RuanYang CaoJianfeng ZhuangHangzhe XuYucong PengZhongyuan ZhangChaoran XuQian YuYin LiZhangqi DouJunwen HuXinyan WuXiaobo YuChi GuShenglong CaoFeng YanChen GaoPublished in: Journal of neuroinflammation (2021)
Our work establishes the role of AXL in the transformation of astrocytes to a phagocytic phenotype via the AXL/STAT1/ABCA1 pathway which contributes to the separation of healthy brain tissue from injury-induced cell debris, further ameliorating neuroinflammation and neurological impairments after TBI. Collectively, our findings provide a potential therapeutic target for TBI.
Keyphrases
- traumatic brain injury
- tyrosine kinase
- severe traumatic brain injury
- cerebral ischemia
- single cell
- high glucose
- diabetic rats
- cell therapy
- white matter
- cell proliferation
- resting state
- stem cells
- oxidative stress
- type diabetes
- protein kinase
- mesenchymal stem cells
- metabolic syndrome
- insulin resistance
- skeletal muscle
- lipopolysaccharide induced
- glycemic control
- weight loss
- mild traumatic brain injury