Nicorandil decreases oxidative stress in slow- and fast-twitch muscle fibers of diabetic rats by improving the glutathione system functioning.

Sarai Sánchez-DuarteSergio Márquez-GamiñoRocío Montoya-PérezErick Andrés Villicaña-GómezKarla Susana Vera-DelgadoCipriana Caudillo-CisnerosFernando Sotelo-BarrosoMa Teresa Melchor-MorenoElizabeth Sánchez-Duarte

Published in: Journal of diabetes investigation (2021)

In diabetic rats, Nicorandil attenuates oxidative stress in slow- and fast-twitch skeletal muscles by improving the glutathione system functioning. The underlying mechanisms for the modulation of glutathione redox state and the transcriptional expression of glutathione metabolism-related genes seem to be fiber type-dependent.

Keyphrases

diabetic rats
oxidative stress
ischemia reperfusion injury
induced apoptosis
dna damage
poor prognosis
transcription factor
skeletal muscle
gene expression
heat shock
signaling pathway