Preoperative environment enrichment preserved neuroligin 1 expression possibly via epigenetic regulation to reduce postoperative cognitive dysfunction in mice.
Jia MinZhongmeng LaiHui WangZhi-Yi ZuoPublished in: CNS neuroscience & therapeutics (2021)
Our results suggest that preoperative EE for 2 weeks reduces POCD. This effect may be mediated by preserving neuroligin 1 expression via attenuating surgery-induced epigenetic dysregulation in the brain.
Keyphrases
- patients undergoing
- poor prognosis
- minimally invasive
- gene expression
- binding protein
- dna methylation
- coronary artery bypass
- type diabetes
- diabetic rats
- resting state
- metabolic syndrome
- skeletal muscle
- oxidative stress
- high fat diet induced
- coronary artery disease
- acute coronary syndrome
- blood brain barrier
- adipose tissue