Increased Expression of IL-10 in Peripheral Blood Mononuclear Cells Correlates with Negative Interferon-γ Release Assay Results in Culture-Confirmed Tuberculosis Patients.

Jidong GuoQiang LiXuxia ZhangCong YaoRongmei LiuYu PangMengqiu Gao

Published in: Infection and drug resistance (2021)

Our data demonstrate that increased IL-10 secretion by PBMCs is inversely correlated with IGRA assay results in culture-confirmed TB patients. Glucocorticoids use and extrapulmonary TB are significantly associated with false-negative IGRA results. Combination testing to measure IL-10 secretion and IFN-γ release is recommended to improve IGRAs specificity.

Keyphrases

end stage renal disease
ejection fraction
mycobacterium tuberculosis
newly diagnosed
prognostic factors
peritoneal dialysis
emergency department
poor prognosis
patient reported outcomes
machine learning
human immunodeficiency virus
deep learning