Systematic analysis of perivascular epithelioid cell neoplasms in the female reproductive tract: a comprehensive review.
Qiulin CuiCheng LiTongyi HuangJiaming HuangMing ChenPublished in: Future oncology (London, England) (2024)
Perivascular epithelioid cell neoplasms (PEComas) are rare mesenchymal lesions, with gynecological PEComas accounting for just over a quarter of cases. Limited reports exist on gynecological PEComa, primarily treated with surgery; adjuvant therapy is considered in high-risk cases. This systematic review aims to summarize the origin and clinical, pathological and molecular characteristics of uterine PEComa, focusing on treatment options for gynecological PEComa. A comprehensive PubMed review of gynecological PEComa reports was conducted. A detailed examination of the literature ensured a thorough understanding. Gynecological PEComa diagnosis relies on histology and immunology. Despite therapy controversies, surgery remains the mainstay. Adjuvant therapy efficacy in high-risk cases is uncertain. mTOR inhibitors are the first line; alternative treatments, including angiogenesis and aromatase inhibitors, should be considered.
Keyphrases
- systematic review
- minimally invasive
- coronary artery bypass
- single cell
- cell therapy
- stem cells
- meta analyses
- endothelial cells
- surgical site infection
- randomized controlled trial
- cell proliferation
- vascular endothelial growth factor
- adverse drug
- acute coronary syndrome
- newly diagnosed
- wound healing
- electronic health record