Neoadjuvant Chemotherapy Is Associated with Altered Immune Cell Infiltration and an Anti-Tumorigenic Microenvironment in Resected Pancreatic Cancer.
Andressa Dias CostaSara A VäyrynenAkhil ChawlaJinming ZhangJuha P VäyrynenMai Chan LauHannah L WilliamsChen YuanVicente Morales-OyarvideDalia ElganainyHarshabad SinghJames M ClearyKimberley J PerezKimmie NgWilliam A Freed-PastorJoseph D ManciasStephanie K DouganJiping WangDouglas A RubinsonRichard F DunneMargaret M KozakLauren K BraisEmma R HillThomas E ClancyDavid C LinehanDaniel T ChangAram F HezelAlbert C KoongAndrew J AguirreBrian M WolpinJonathan Andrew NowakPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Neoadjuvant chemotherapy with FOLFIRINOX shifts the PDAC immune microenvironment toward an anti-tumorigenic state associated with improved patient survival.