Synthesis of acridone derivatives via heterologous expression of a plant type III polyketide synthase in Escherichia coli.
Gyu-Sik ChoiHye Jeong ChooBong-Gyu KimJoong-Hoon AhnPublished in: Microbial cell factories (2020)
Two bioactive acridone derivatives were synthesized by expressing type III plant polyketide synthases and other genes in E. coli, which increased the supplement of substrates. This study showed that is possible to synthesize diverse polyketides in E. coli using plant polyketide synthases.