Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma.

Justine S ParadisMonica Acosta Robert Saddawi-KonefkaAyush KishoreFrederico GomesNadia ArangManoela TiagoSilvia ComaSimone LubranoXingyu WuKyle FordChi-Ping DayGlenn MerlinoPrashant MaliJonathan A Pachter Takami Sato Andrew E AplinJ Silvio Gutkind

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Coupling the unique genetic landscape of uveal melanoma with the power of unbiased genetic screens, our studies reveal that FAK and MEK-ERK cotargeting may provide a new network-based precision therapeutic strategy for mUM treatment.See related commentary by Harbour, p. 2967.

Keyphrases

genome wide
dna methylation
pi k akt
copy number
signaling pathway
single cell
skin cancer
cell migration
high throughput
cell proliferation
pain management
room temperature
chronic pain