Andrew E Aplin

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 38

Top Topics

Top Venues

Science signaling

Cancer research

Cell death discovery

Molecular cancer therapeutics

This page only lists publications with an associated author ORCID identifier.

Publications

Vivian Chua, Melisa Lopez-Anton, Mizue Terai, Ryota Tanaka, Usman Baqai, Timothy J Purwin, Jelan I Haj, Francis J Waltrich, Isabella V Trachtenberg, Kristine Luo, Rohith Tudi, Angela Jeon, Anna Han, Inna Chervoneva, Michael A Davies, Julio A Aguirre-Ghiso, Takami Sato, Andrew E Aplin
Slow proliferation of BAP1-deficient uveal melanoma cells is associated with reduced S6 signaling and resistance to nutrient stress. Science signaling 17 (840) (2024)
Maria R Cavallo, Jacob C Yo, Kayla C Gallant, Camille J Cunanan, Amirali Amirfallah, Marzieh Daniali, Alyssa B Sanders, Andrew E Aplin, Edmund A Pribitkin, Edward J Hartsough
Mcl-1 mediates intrinsic resistance to RAF inhibitors in mutant BRAF papillary thyroid carcinoma. Cell death discovery 10 (1) (2024)
Maria R Cavallo, Jacob C Yo, Kayla C Gallant, Camille J Cunanan, Amirali Amirfallah, Marzieh Daniali, Alyssa B Sanders, Andrew E Aplin, Edmund A Pribitkin, Edward J Hartsough
Mcl-1 mediates intrinsic resistance to RAF inhibitors in mutant BRAF papillary thyroid carcinoma. Cell death discovery 10 (1) (2024)
Vivian Chua, Melisa Lopez-Anton, Mizue Terai, Ryota Tanaka, Usman Baqai, Timothy J Purwin, Jelan I Haj, Francis J Waltrich, Isabella V Trachtenberg, Kristine Luo, Rohith Tudi, Angela Jeon, Anna Han, Inna Chervoneva, Michael A Davies, Julio A Aguirre-Ghiso, Takami Sato, Andrew E Aplin
Slow proliferation of BAP1-deficient uveal melanoma cells is associated with reduced S6 signaling and resistance to nutrient stress. Science signaling 17 (840) (2024)
Maria R Cavallo, Jacob C Yo, Kayla C Gallant, Camille J Cunanan, Amirali Amirfallah, Marzieh Daniali, Alyssa B Sanders, Andrew E Aplin, Edmund A Pribitkin, Edward J Hartsough
Mcl-1 mediates intrinsic resistance to RAF inhibitors in mutant BRAF papillary thyroid carcinoma. Cell death discovery 10 (1) (2024)
Maria R Cavallo, Jacob C Yo, Kayla C Gallant, Camille J Cunanan, Amirali Amirfallah, Marzieh Daniali, Alyssa B Sanders, Andrew E Aplin, Edmund A Pribitkin, Edward J Hartsough
Mcl-1 mediates intrinsic resistance to RAF inhibitors in mutant BRAF papillary thyroid carcinoma. Cell death discovery 10 (1) (2024)
Vivian Chua, Melisa Lopez-Anton, Mizue Terai, Ryota Tanaka, Usman Baqai, Timothy J Purwin, Jelan I Haj, Francis J Waltrich, Isabella V Trachtenberg, Kristine Luo, Rohith Tudi, Angela Jeon, Anna Han, Inna Chervoneva, Michael A Davies, Julio A Aguirre-Ghiso, Takami Sato, Andrew E Aplin
Slow proliferation of BAP1-deficient uveal melanoma cells is associated with reduced S6 signaling and resistance to nutrient stress. Science signaling 17 (840) (2024)
Vivian Chua, Melisa Lopez-Anton, Mizue Terai, Ryota Tanaka, Usman Baqai, Timothy J Purwin, Jelan I Haj, Francis J Waltrich, Isabella V Trachtenberg, Kristine Luo, Rohith Tudi, Angela Jeon, Anna Han, Inna Chervoneva, Michael A Davies, Julio A Aguirre-Ghiso, Takami Sato, Andrew E Aplin
Slow proliferation of BAP1-deficient uveal melanoma cells is associated with reduced S6 signaling and resistance to nutrient stress. Science signaling 17 (840) (2024)
Dan Filipescu, Saul Carcamo, Aman Agarwal, Navpreet Tung, Etienne Humblin, Matthew S Goldberg, Nikki S Vyas, Kristin G Beaumont, Deniz Demircioglu, Subhasree Sridhar, Flavia G Ghiraldini, Claudia Capparelli, Andrew E Aplin, Hélène Salmon, Robert P Sebra, Alice Oliffson Kamphorst, Miriam Merad, Dan Hasson, Emily Bernstein
MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping. Nature cell biology (2023)
Sheera R Rosenbaum, Signe Caksa, Casey D Stefanski, Isabella V Trachtenberg, Haley P Wilson, Nicole A Wilski, Connor A Ott, Timothy J Purwin, Jelan I Haj, Danielle Pomante, Daniel Kotas, Inna Chervoneva, Claudia Capparelli, Andrew E Aplin
SOX10 loss sensitizes melanoma cells to cytokine-mediated inflammatory cell death. Molecular cancer research : MCR (2023)
McKenna Q Glasheen, Signe Caksa, Amelia G Young, Nicole A Wilski, Connor A Ott, Inna Chervoneva, Keith T Flaherty, Meenhard Herylyn, George X Xu, Andrew E Aplin, Claudia Capparelli
Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma. Molecular cancer therapeutics (2023)
Anna Han, Vivian Chua, Usman Baqai, Timothy J Purwin, Nelisa Bechtel, Emily Hunter, Manoela Tiago, Erin Seifert, David W Speicher, Zachary T Schug, J William Harbour, Andrew E Aplin
Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma. Oncogene 41 (8) (2022)
Signe Caksa, Andrew E Aplin
PROactively TACkling CDK4/6 therapy resistance. Nature cancer 2 (4) (2022)
Claudia Capparelli, Timothy J Purwin, McKenna Q Glasheen, Signe Caksa, Manoela Tiago, Nicole A Wilski, Danielle Pomante, Sheera Rosenbaum, Mai Q Nguyen, Weijia Cai, Janusz Franco-Barraza, Richard Zheng, Gaurav Kumar, Inna Chervoneva, Ayako Shimada, Vito W Rebecca, Adam E Snook, Kim Hookim, Xiaowei Xu, Edna Cukierman, Meenhard Herylyn, Andrew E Aplin
Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma. Nature communications 13 (1) (2022)
Weijia Cai, Mai Q Nguyen, Nicole A Wilski, Timothy J Purwin, Megane Vernon, Manoela Tiago, Andrew E Aplin
A Genome-Wide Screen Identifies PDPK1 as a Target to Enhance the Efficacy of MEK1/2 Inhibitors in NRAS Mutant Melanoma. Cancer research 82 (14) (2022)
Amy E Leader, Andrew E Aplin
From the Community to the Bench and Back Again: The Value of Patient and Community Engagement in Cancer Research. Cancer discovery 11 (9) (2022)
Usman Baqai, Timothy J Purwin, Nelisa Bechtel, Vivian Chua, Anna Han, Edward J Hartsough, Jeffim N Kuznetsov, J William Harbour, Andrew E Aplin
Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma. Molecular cancer research : MCR 20 (8) (2022)
Imène Krossa, Thomas Strub, Andrew E Aplin, Robert Ballotti, Corine Bertolotto
Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma? Cancers 14 (19) (2022)
Megane Vernon, Nicole A Wilski, Daniel Kotas, Weijia Cai, Danielle Pomante, Manoela Tiago, Emad S Alnemri, Andrew E Aplin
Raptinal Induces Gasdermin E-Dependent Pyroptosis in Naïve and Therapy-Resistant Melanoma. Molecular cancer research : MCR 20 (12) (2022)
Claudia Capparelli, Andrew E Aplin
Packing a Punch against PD-L1. Cancer discovery 12 (6) (2022)
Dominic Lapadula, Bao Lam, Mizue Terai, Tsuyoshi Takahashi, Ryota Tanaka, Eduardo F Farias, Rama Kadamb, Melissa Lopez-Anton, Christian C Heine, Bhavik Modasia, Julio A Aguirre-Ghiso, Andrew E Aplin, Takami Sato, Jeffrey L Benovic
IGF1R inhibition enhances the therapeutic effects of Gq/11 inhibition in metastatic uveal melanoma progression. Molecular cancer therapeutics (2022)
Justine S Paradis, Monica Acosta, Robert Saddawi-Konefka, Ayush Kishore, Frederico Gomes, Nadia Arang, Manoela Tiago, Silvia Coma, Simone Lubrano, Xingyu Wu, Kyle Ford, Chi-Ping Day, Glenn Merlino, Prashant Mali, Jonathan A Pachter, Takami Sato, Andrew E Aplin, J Silvio Gutkind
Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (11) (2021)
Sheera R Rosenbaum, Nicole A Wilski, Andrew E Aplin
Fueling the Fire: Inflammatory Forms of Cell Death and Implications for Cancer Immunotherapy. Cancer discovery 11 (2) (2021)
Andrew E Aplin, Claudia Capparelli
Combined SHPments: An Effective Therapeutic Strategy for MPNST. Cancer research 81 (2) (2021)
Vivian Chua, Anna Han, Nelisa Bechtel, Timothy J Purwin, Emily Hunter, Connie Liao, J William Harbour, Andrew E Aplin
The AMP-dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma. Pigment cell & melanoma research (2021)
Anna Han, Timothy J Purwin, Andrew E Aplin
Roles of the BAP1 Tumor Suppressor in Cell Metabolism. Cancer research 81 (11) (2021)
Jessica L F Teh, Dan A Erkes, Phil Fang Cheng, Manoela Tiago, Nicole A Wilski, Conroy O Field, Inna Chervoneva, Mitch P Levesque, George X Xu, Reinhard Dummer, Andrew E Aplin
Activation of CD8+ T Cells Contributes to Antitumor Effects of CDK4/6 Inhibitors plus MEK Inhibitors. Cancer immunology research 8 (9) (2020)
Jessica L F Teh, Timothy J Purwin, Anna Han, Vivian Chua, Prem Patel, Usman Baqai, Connie Liao, Nelisa Bechtel, Takami Sato, Michael A Davies, Julio Aguirre-Ghiso, Andrew E Aplin
Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma. Molecular cancer therapeutics 19 (8) (2020)
Anna Han, Timothy J Purwin, Nelisa Bechtel, Connie Liao, Vivian Chua, Erin Seifert, Takami Sato, Zachary T Schug, David W Speicher, J William Harbour, Andrew E Aplin
BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors. Oncogene 40 (3) (2020)
Vivian Chua, Jane Mattei, Anna Han, Lauren Johnston, Kyleigh LiPira, Sara M Selig, Richard D Carvajal, Andrew E Aplin, Sapna Pradyuman Patel
The Latest on Uveal Melanoma Research and Clinical Trials: Updates from the Cure Ocular Melanoma (CURE OM) Science Meeting (2019). Clinical cancer research : an official journal of the American Association for Cancer Research 27 (1) (2020)
Michael J Vido, Justin Rock, Andrew E Aplin
Role of serine 365 in BRAF V600E sensitivity to RAF inhibition. Pigment cell & melanoma research 34 (4) (2020)
Seungwon Yang, Jiangbo Wei, Yan-Hong Cui, Gayoung Park, Palak Shah, Yu Deng, Andrew E Aplin, Zhike Lu, Seungmin Hwang, Chuan He, Yu-Ying He
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. Nature communications 10 (1) (2019)
Dan A Erkes, Weijia Cai, Ileine M Sanchez, Timothy J Purwin, Corey Rogers, Conroy O Field, Adam C Berger, Edward J Hartsough, Ulrich Rodeck, Emad S Alnemri, Andrew E Aplin
Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis. Cancer discovery 10 (2) (2019)
Grazia Ambrosini, Catherine Do, Benjamin Tycko, Ronald B Realubit, Charles Karan, Elgilda Musi, Richard D Carvajal, Vivian Chua, Andrew E Aplin, Gary K Schwartz
Inhibition of NF-κB-Dependent Signaling Enhances Sensitivity and Overcomes Resistance to BET Inhibition in Uveal Melanoma. Cancer research 79 (9) (2019)
Vivian Chua, Marlana Orloff, Jessica Lf Teh, Takahito Sugase, Connie Liao, Timothy J Purwin, Bao Q Lam, Mizue Terai, Grazia Ambrosini, Richard D Carvajal, Gary Schwartz, Takami Sato, Andrew E Aplin
Stromal fibroblast growth factor 2 reduces the efficacy of bromodomain inhibitors in uveal melanoma. EMBO molecular medicine 11 (2) (2019)
Dan A Erkes, Sheera R Rosenbaum, Conroy O Field, Inna Chervoneva, Jessie Villanueva, Andrew E Aplin
PLX3397 inhibits the accumulation of intra-tumoral macrophages and improves bromodomain and extra-terminal inhibitor efficacy in melanoma. Pigment cell & melanoma research 33 (2) (2019)
Ileine M Sanchez, Timothy J Purwin, Inna Chervoneva, Dan A Erkes, Mai Q Nguyen, Michael A Davies, Katherine L Nathanson, Kristel Kemper, Daniel S Peeper, Andrew E Aplin
In Vivo ERK1/2 Reporter Predictively Models Response and Resistance to Combined BRAF and MEK Inhibitors in Melanoma. Molecular cancer therapeutics 18 (9) (2019)
Nicole A Wilski, Christina Del Casale, Timothy J Purwin, Andrew E Aplin, Christopher M Snyder
Murine Cytomegalovirus Infection of Melanoma Lesions Delays Tumor Growth by Recruiting and Repolarizing Monocytic Phagocytes in the Tumor. Journal of virology 93 (20) (2019)