Putting the Microenvironment into the Immunotherapy Companion Diagnostic.

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

A post hoc analysis in advanced gastric cancer showed stronger association of programmed cell death-ligand 1 (PD-L1) with immunotherapy efficacy measured by combined positive score (CPS) compared with tumor cells (TC%). This finding suggests expression in immune cells in the tumor microenvironment increases the value of the companion diagnostic test.See related article by Lei et al., p. 3926.

Keyphrases

poor prognosis
stem cells
neoadjuvant chemotherapy
squamous cell carcinoma
radiation therapy
long non coding rna
binding protein