Login / Signup

Prevention of schizophrenia deficits via non-invasive adolescent frontal cortex stimulation in rats.

Ravit HadarRebecca WinterHenriette Edemann-CallesenFranziska WieskeBettina HabeltNiranjan KhadkaViktoria Felgel-FarnholzElizabeth Barroeta-HlusickaJanine ReisCristian Alexandru TatarauKlaus FunkeBrita FritschNadine BernhardtMarom BiksonMichael A NitscheChristine Winter
Published in: Molecular psychiatry (2019)
Schizophrenia is a severe neurodevelopmental psychiatric affliction manifested behaviorally at late adolescence/early adulthood. Current treatments comprise antipsychotics which act solely symptomatic, are limited in their effectiveness and often associated with side-effects. We here report that application of non-invasive transcranial direct current stimulation (tDCS) during adolescence, prior to schizophrenia-relevant behavioral manifestation, prevents the development of positive symptoms and related neurobiological alterations in the maternal immune stimulation (MIS) model of schizophrenia.
Keyphrases