Novel Therapeutic Targets on the Horizon: An Analysis of Clinical Trials on Therapies for Bone Metastasis in Prostate Cancer.
Wenhao ZhouWei ZhangShi YanKaixuan ZhangHan WuHongyu ChenMinfeng ShiTie ZhouPublished in: Cancers (2024)
In the absence of early detection and initial treatment, prostate cancer often progresses to an advanced stage, frequently spreading to the bones and significantly impacting patients' well-being and healthcare resources. Therefore, managing patients with prostate cancer that has spread to the bones often involves using bone-targeted medications like bisphosphonates and denosumab to enhance bone structure and minimize skeletal complications. Additionally, researchers are studying the tumor microenvironment and biomarkers to understand the mechanisms and potential treatment targets for bone metastases in prostate cancer. A literature search was conducted to identify clinical studies from 2013 to 2023 that focused on pain, performance status, or quality of life as primary outcomes. The analysis included details such as patient recruitment, prior palliative therapies, baseline characteristics, follow-up, and outcome reporting. The goal was to highlight the advancements and trends in bone metastasis research in prostate cancer over the past decade, with the aim of developing strategies to prevent and treat bone metastases and improve the quality of life and survival rates for prostate cancer patients.
Keyphrases
- prostate cancer
- radical prostatectomy
- bone mineral density
- healthcare
- clinical trial
- soft tissue
- postmenopausal women
- systematic review
- bone loss
- ejection fraction
- metabolic syndrome
- chronic pain
- emergency department
- palliative care
- cancer therapy
- type diabetes
- neuropathic pain
- newly diagnosed
- randomized controlled trial
- body composition
- chronic kidney disease
- spinal cord
- risk assessment
- prognostic factors
- adverse drug
- electronic health record
- patient reported outcomes
- free survival