Rap2c as a Novel Biomarker for Predicting Poor Prognosis in Glioma.
Xiucun WangCheng WangLin XiZhengquan YuPublished in: OncoTargets and therapy (2020)
These findings indicate that high Rap2c expression predicts poor prognosis in glioma. Rap2c-mediated ERK1/2 phosphorylation initiates EMT cascade and promotes migration and invasion of glioma cells. Thus, targeting Rap2c and ERK signaling pathway could be a novel treatment modality for glioma.