Targeting the NLRP3 inflammasome reduces inflammation in hidradenitis suppurativa skin.

Barry MoranConor M SmithAlexandra ZabarowskiMark RyanJozsef KarmanRobert W DunstanKathleen M SmithRoisin HamblyJana MusilovaAndreea PetrascaAurelie FabreMargaret O'DonnellKarsten HokampKingston H G MillsWilliam J HousleyDesmond C WinterBrian Kirby Jean M Fletcher

Published in: The British journal of dermatology (2023)

These data provide a rationale for targeting the NLRP3 inflammasome in HS using small molecule inhibitors which are currently being tested for other indications.

Keyphrases

nlrp inflammasome
small molecule
hidradenitis suppurativa
cancer therapy
oxidative stress
clinical trial
electronic health record
protein protein
soft tissue
wound healing
machine learning
artificial intelligence