The Jafron series of sorbent cartridges provides a comprehensive array of coated, highly biocompatible sorbent beads made of styrene-divinylbenzene copolymers. Such beads carry a mean diameter of 0.8 mm with a range from 0.60 to 1.18 mm. The maximal pore size of these coated beads and the volume of the cartridge vary according to the type of cartridge ranging between 50 Da and 60 kDa. The sorbents, the size of the cartridge, the volume of sorbent, and the pore size (which reaches 60 kDa with the HA330 cartridge) aim to take advantage of the principles of molecular adsorption in a variety of diseases from uremic toxin retention to poisoning and drug overdose, from kidney disease to liver failure, from acute respiratory distress syndrome to sepsis, from toxic skin injury to COVID-19. The preliminary data from ex vivo studies, animal investigations, and human pilot work look promising and justify a program of systematic investigation of these products to advance our understanding of how they may be incorporated into our therapeutic arsenal.
Keyphrases
- solid phase extraction
- acute respiratory distress syndrome
- liver failure
- molecularly imprinted
- extracorporeal membrane oxygenation
- coronavirus disease
- mechanical ventilation
- tandem mass spectrometry
- heat shock protein
- endothelial cells
- aqueous solution
- sars cov
- simultaneous determination
- hepatitis b virus
- escherichia coli
- gas chromatography
- liquid chromatography
- metal organic framework
- acute kidney injury
- heart rate
- electronic health record
- high resolution
- clinical trial
- high throughput
- randomized controlled trial
- mass spectrometry
- blood pressure
- resistance training
- big data
- machine learning
- induced pluripotent stem cells
- drug release
- optical coherence tomography
- case control
- respiratory syndrome coronavirus