Toxicity of iron oxide nanoparticles: Size and coating effects.
Maxim A AbakumovAlevtina S SemkinaAlexander S SkorikovDaniil A VishnevskiyAnna V IvanovaElena MironovaGalina A DavydovaAlexander G MajougaVladimir P ChekhoninPublished in: Journal of biochemical and molecular toxicology (2018)
Toxicological research of novel nanomaterials is a major developmental step of their clinical approval. Since iron oxide magnetic nanoparticles have a great potential in cancer treatment and diagnostics, the investigation of their toxic properties is very topical. In this paper we synthesized bovine serum albumin-coated iron oxide nanoparticles with different sizes and their polyethylene glycol derivative. To prove high biocompatibility of obtained nanoparticles the number of in vitro toxicological tests on human fibroblasts and U251 glioblastoma cells was performed. It was shown that albumin nanoparticles' coating provides a stable and biocompatible shell and prevents cytotoxicity of magnetite core. On long exposure times (48 hours), cytotoxicity of iron oxide nanoparticles takes place due to free radical production, but this toxic effect may be neutralized by using polyethylene glycol modification.
Keyphrases
- iron oxide nanoparticles
- magnetic nanoparticles
- iron oxide
- oxide nanoparticles
- induced apoptosis
- endothelial cells
- cell cycle arrest
- oxidative stress
- induced pluripotent stem cells
- endoplasmic reticulum stress
- extracellular matrix
- ionic liquid
- mouse model
- pluripotent stem cells
- drug release
- signaling pathway
- drug delivery
- cell death
- cell proliferation