Systemic counterregulatory response of angiopoietin-2 after aflibercept therapy for nAMD: a potential escape mechanism.

Reinhard Angermann Teresa RaucheggerYvonne NowosielskiChristof SeifarthStefan EggerMartina T KralingerGerhard F KieselbachClaus Zehetner

Published in: Acta ophthalmologica (2020)

In this study, we report significant systemic upregulation of Ang2 after intravitreal aflibercept administration. This counterregulatory response may represent a potential escape mechanism from antiangiogenic therapy.

Keyphrases

age related macular degeneration
angiotensin ii
human health
poor prognosis
vascular endothelial growth factor
cell proliferation
stem cells
signaling pathway
risk assessment
drug induced
optical coherence tomography
cell therapy