Cardiometabolic Disease Staging Predicts Effectiveness of Weight-Loss Therapy to Prevent Type 2 Diabetes: Pooled Results From Phase III Clinical Trials Assessing Phentermine/Topiramate Extended Release.
Fangjian GuoW Timothy GarveyPublished in: Diabetes care (2017)
Numbers needed to treat to prevent one case of type 2 diabetes are markedly lower in patients with high-risk scores. CMDS can be used to quantify risk of diabetes in overweight/obese individuals and predict the effectiveness of weight-loss therapy to prevent diabetes.
Keyphrases
- weight loss
- glycemic control
- type diabetes
- phase iii
- clinical trial
- bariatric surgery
- roux en y gastric bypass
- gastric bypass
- cardiovascular disease
- open label
- randomized controlled trial
- systematic review
- phase ii
- metabolic syndrome
- weight gain
- lymph node
- double blind
- obese patients
- mesenchymal stem cells
- insulin resistance
- study protocol
- physical activity
- bone marrow