Reduced CDHR3 expression in children wheezing with rhinovirus.
Katarina Stenberg HammarKatarzyna NiespodzianaMarianne van HageJuha KereRudolf ValentaGunilla HedlinCilla SöderhällPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2018)
Preschool children with RV-induced wheezing were shown to have reduced CDHR3 mRNA levels, which might result in an increased permeability of the epithelial layers of the airways and thereby an increased vulnerability. Thus, measuring CDHR3 mRNA levels might help to identify a more severe phenotype of wheezing preschool children.