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Copy Number Variations in Neuropsychiatric Disorders.

Gergely BükiKinga HadzsievJudit Bene
Published in: International journal of molecular sciences (2023)
Neuropsychiatric disorders are complex conditions that represent a significant global health burden with complex and multifactorial etiologies. Technological advances in recent years have improved our understanding of the genetic architecture of the major neuropsychiatric disorders and the genetic loci involved. Previous studies mainly investigated genome-wide significant SNPs to elucidate the cross-disorder and disorder-specific genetic basis of neuropsychiatric disorders. Although copy number variations represent a major source of genetic variations, they are known risk factors in developing a variety of human disorders, including certain neuropsychiatric diseases. In this review, we demonstrate the current understanding of CNVs contributing to liability for schizophrenia, bipolar disorder, and major depressive disorder.
Keyphrases
  • genome wide
  • copy number
  • bipolar disorder
  • major depressive disorder
  • mitochondrial dna
  • dna methylation
  • risk factors
  • global health
  • gene expression
  • public health
  • endothelial cells