Thy-1 predicts poor prognosis and is associated with self-renewal in ovarian cancer.
Elizabeth V ConnorCaner SayginChad BraleyAndrew C WiechertSheelarani KarunanithiKatie Crean-TateFadi W Abdul-KarimChad M MichenerPeter G RoseJustin D LathiaOfer ReizesPublished in: Journal of ovarian research (2019)
Thy-1 is a marker of ovarian CSCs. Increased expression of Thy-1 in EOC predicts poor prognosis and is associated with increased proliferative and self-renewal capacity. Thy-1 knockdown decreases proliferative and self-renewal capacity, and represents a potential therapeutic target.