Mechanism of microRNA-22 in regulating neuroinflammation in Alzheimer's disease.
Chenyang HanLi GuoYi YangQiaobing GuanHeping ShenYongjia ShengQingcai JiaoPublished in: Brain and behavior (2020)
miRNA-22 was negatively correlated with the expression of inflammatory factors in AD patients, and miRNA-22 could inhibit the release of inflammatory cytokines by regulating the inflammatory pyroptosis of glial cells via targeting GSDMD, thereby improving cognitive ability in AD mice. miRNA-22 and pyroptosis are potential novel therapeutic targets in the treatment of AD.
Keyphrases
- end stage renal disease
- newly diagnosed
- oxidative stress
- ejection fraction
- induced apoptosis
- poor prognosis
- chronic kidney disease
- prognostic factors
- cell cycle arrest
- peritoneal dialysis
- type diabetes
- neuropathic pain
- cognitive impairment
- patient reported outcomes
- binding protein
- skeletal muscle
- risk assessment
- combination therapy
- metabolic syndrome
- long non coding rna
- brain injury
- human health
- high fat diet induced
- spinal cord injury
- climate change
- inflammatory response
- endoplasmic reticulum stress
- subarachnoid hemorrhage
- blood brain barrier
- cerebral ischemia
- replacement therapy
- pi k akt
- drug delivery