Trial of Three Rounds of Mass Azithromycin Administration for Yaws Eradication.
Lucy N JohnCamila G BeirasWendy HouineiMonica MedappaMaria SabokReman KolmauEunice JonathanEdward MaikaJames K WangiPetra PospíšilováDavid ŠmajsDan OuchiIván Galván-FemeníaMathew A BealeLorenzo GiacaniBonaventura ClotetEric Q MooringMichael MarksMartí Vall-MayansOriol MitjàPublished in: The New England journal of medicine (2022)
The reduction in the community prevalence of yaws was greater with three rounds of mass administration of azithromycin at 6-month intervals than with one round of mass administration of azithromycin followed by two rounds of targeted treatment. Monitoring for the emergence and spread of antimicrobial resistance is needed. (Funded by Fundació "la Caixa" and others; ClinicalTrials.gov number, NCT03490123.).