Near-Apneic Ventilation Decreases Lung Injury and Fibroproliferation in an Acute Respiratory Distress Syndrome Model with Extracorporeal Membrane Oxygenation.

Joaquin AraosLeyla AlegriaPatricio GarciaPablo CrucesDagoberto SotoBenjamín ErranzMacarena AmthauerTatiana SalomonTania MedinaFelipe RodriguezPedro AyalaGisella R BorzoneManuel MenesesFelipe DamianiJaime RetamalRodrigo CornejoGuillermo BugedoAlejandro Bruhn

Published in: American journal of respiratory and critical care medicine (2020)

In an acute respiratory distress syndrome model supported with ECMO, near-apneic ventilation decreased histologic lung injury and matrix metalloproteinase activity, and prevented the expression of myofibroblast markers.

Keyphrases

acute respiratory distress syndrome
extracorporeal membrane oxygenation
mechanical ventilation
respiratory failure
poor prognosis
intensive care unit
transforming growth factor
epithelial mesenchymal transition
signaling pathway